Skype4Pyを使う

簡単．

% sudo easy_install Skype4Py

sample.py

# coding: utf-8

import sys
import Skype4Py
import time

skype = Skype4Py.Skype()
skype.Attach()
topic = u"ブックマークしたチャット部屋の名前"
for ch in skype.BookmarkedChats:
  if ch.Topic == topic:
    chat = ch
while True :
  chat.SendMessage(u"miettalが時刻をお知らせします．只今の時刻は"+
    time.strftime("%a, %d %b %Y %H:%M:%S +0000", time.localtime())+u"です．")